MG_127 – Spx subfamily protein
Name | ||
---|---|---|
WID | MG_127 |
![]() |
Name | Spx subfamily protein |
![]() |
Symbol | spx | |
Synonyms | yjbD | |
Protein product | MG_127_MONOMER | |
Cross references | GenBank: AAC71345.1, CMR: MG_127, BioCyc: MG_127, SwissProt: P47373 | |
Homologs | ||
Classification | ||
Type | mRNA |
![]() |
Structure | ||
Structure |
![]() |
|
Sequence | Chromosome: Mgenitalium_Chr_1, Coordinate: 154999 (nt), Length: 438 (nt), Direction: Forward, G/C content: 31.5%, Sequence: 1 51 101 151 201 251 301 351 401 ATGAAAAAAGCGGGTAAAAAAAATAGTGATGCAGGTAAGACTTTTATCTT AATCTCATCATCCTGTTCATCCTGTCAGAAAGCCATTGAGTTTTTTGATC AAAACAAAATTAGCTATGTTGTTGAGAATTTTTATAAAAAACCAATTAGT GATAAGCGTTTTAAAGATATTTTAAGTCTTAGTGAGGATGGTACTGAAAG TTTGTTTTCCAAACGTGCTGATCAGATTAAAGCAACTAACAGTGTTAGTG TTGAAGAGTTGAGTATCAGTGAATTAATTAAGCTAGTTAGAGAACGTCCT TCTTTACTAAGAAGGCCTATTATCATCCAATATAATTCTTCAGGAATTCC TAAAAGGATGCGAATTGGTTATAACTCATCTGAAATTAAGGTCTTTGAGC GTAAACTAATAGAACCAAAGCCTATAATACAACAATAA 50 100 150 200 250 300 350 400 438 |
![]() |
Transcription unit | TU_078 |
![]() |
Empirical formula (pH 7.5) | H4679C4240N1770O3047P438 | |
Molecular weight (pH 7.5; Da) | 142749.89 |
![]() |
Functional genomics | ||
Is essential | Yes (Show evidence) |
![]() |
Relative expression | 1.96428 (dimensionless) (Show evidence) |
![]() |
Half life | 4.425 (min) (Show evidence) |
![]() |
Extinction coefficient (260 nm, 25C, pH 7.0) |
4554200 | |
pI | 3.95 | |
Comments | ||
Comments | major function is to restore thiol balance under disulfide stress through transcriptional regulation [PUB_0112]; upregulatex trxA, trxB [PUB_0112]; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress [PUB_0096]; inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex formation between RNAP and certain transcriptional activator proteins like ResD and ComA. In response to oxidative stress, Spx can also activate transcription, making it a general regulator that exerts both positive and negative control over transcription initiation [PUB_0110]; regulated by clpP protease [PUB_0111]; | |
References |
|
|
Metadata | ||
Created | 2012-10-01 15:07:15 | |
Last updated | 2012-10-01 15:12:57 |