MG_015 – multidrug ABC transporter, ATP-binding/permease protein

Name
WID MG_015 View in model
Name multidrug ABC transporter, ATP-binding/permease protein View in model
Symbol mdlB
Synonyms lmrA
Protein product MG_015_MONOMER
Cross references GenBank: AAC71231.1, CMR: MG_015, BioCyc: MG_015, SwissProt: P47261
Homologs
 
Classification
Type mRNA View in model
 
Structure
Structure 1497321743 MG_014 MG_015 MG_018 View in model
Sequence Chromosome: Mgenitalium_Chr_1, Coordinate: 17473 (nt), Length: 1770 (nt), Direction: Forward, G/C content: 29.8%, Sequence:
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ATGGAAGGAAGTTGAAGTTATAAATTACTTTATGTTTTTTTGTGTATAGT
TCTTGGTATTTTATATGGAATTGCTAACCCTATCTTATTAGCACAAGGTC
TTGGTTTTATTTTTCCTATTACTAGTAGTAATGGTCGTGCTGTTGACTCA
ATATATTCATTAATTTACCCAACAAATTTAAATGTATTCATTAGGCTCAC
AATTGTGAGCGTAACTGTTTTTGTAGCTTATGCATTAATCTTTGTATTTA
ATGTAGCGCAAAACTATGTAGGGATTAAACTTTACCAACAAACATGTGCT
ACTTTGCGTTGAAAGGCATATTTAAAAATGCAGAGTATGTCAACCAGCTT
TTTTGATACGCAAAATAATGGTGATCTTATGAGTAGGTTAACTAATGATA
TGTATAACATTGATAACCTATTCACTCAAGCTGGTGGACAAGCTATTCAA
AGTTTGTTTAATATTTTAACAACCTCAGTATTAATATTTTTATTAAGCCC
AGTTATTGCACTTATTTCACTTTCAATTTTAGCTACATTAATTACTTTTT
CTTTTGCCTTTCTAAAGAAATCAAAAACTTCATATAGTCAAGTACAAAAT
AATTTGGGTGATATGTCTGGTTATATTGAAGAGGTTTTAACTAATCATAA
GGTTGTTCATGTCTTGAAGTTGCAAGAGATAATGATTAAGGATTTTGATC
AATACAACAAATCAATGATCAAACCAACTGTAAGAGGGAATACATATTCG
ATCTTTCTTTTTTCTTGGTTTGGTTTTATATCAAATATTACTTATCTGGT
TTCTATATCAATTGCTACTGCTTTTAGTGTTAATTCTATTCCTTCATTTG
GAATTAGTGTTATTAACTATTCATTCATGTTGTCTTACATTGCTTCTTTA
AGGCAAATAACTTTAGCATTAGATCAAATCTTTACCCTTTGAAACTTAGT
TCAATTAGGGGTTGTTAGTGCAGAAAGAGTATTTAAGGTATTAGATCTTA
ATGTAGAGAAAGATACTGCTACTATTGACAAATTACCTGATATTAAAGGT
AATATAAGGTTTGAAAATGTAGCATTTGGTTACAATAAAGATAAACCTAC
TTTAACAGGAATTAACTTTAGTGTTAAACATGGAGATGTAGTTGCAATAG
TAGGTCCTACAGGAGCTGGTAAATCAACTATTATTAATCTATTGATGAAA
TTCTATAAACCTTTTGAAGGAAAGATTTATATGGATAACTTTGAAATTAG
TGATGTAACTAAAAAAGCATGAAGAGAAAAGATTTCTATAGTATTACAAG
ATTCATTCTTATTTAGCGGCACAATTAAAGAAAATATTCGTTTAGGCAGA
CAGGATGCTACTGATGATGAGATTATCGCTGCATGTAAAACTGCTAATGC
TCATGATTTCATCATGCGTTTACCAAAAGGATATGACACTTATATTTCCA
ATAAAGCAGATTATCTTTCTGTTGGTGAAAGGCAATTATTAACAATTGCC
AGAGCAGTAATCCGTAATGCTCCAGTTTTGCTCTTAGATGAAGCAACTAG
TTCAGTTGATGTCCATTCAGAAAAATTAATTCAAGAATCAATAGGAAGGT
TAATGAAAAATAAAACTTCTTTTATAATTTCTCATCGTCTTTCAATTATT
CGTGATGCAACATTAATAATGGTTATTAATGATGGTAAAGTACTTGAAAT
GGGTAATCATGATCAGCTGATGAAACAAAATGGATTTTATGCACGTTTAA
AACAATCTTCGGTTCGTTAA
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View in model
Transcription unit TU_008 View in model
Empirical formula (pH 7.5) H18819C17048N6894O12452P1770
Molecular weight (pH 7.5; Da) 574336.43 View in model
 
Functional genomics
Is essential
Yes (Show evidence)
View in model
Relative expression
0.851454 (dimensionless) (Show evidence)
View in model
Half life
5.6 (min) (Show evidence)
View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)
18353300
pI 4.34
 
Comments
Comments no predicted substrate binding protein in M. genitalium; similar to multidrug resistant transporters of eukarya [PUB_0241, PUB_0439, PUB_0440]; functions as dimer;
References
  1. Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A 99, 9697-702 (2002). WholeCell: PUB_0602, PubMed: 12119387

  2. Glass JI, Assad-Garcia N, Alperovich N, Yooseph S, Lewis MR, Maruf M, Hutchison CA 3rd, Smith HO, Venter JC. Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A 103, 425-30 (2006). WholeCell: PUB_0193, PubMed: 16407165

  3. Kuroda T, Tsuchiya T. Multidrug efflux transporters in the MATE family. Biochim Biophys Acta 1794, 763-8 (2009). WholeCell: PUB_0241, PubMed: 19100867

  4. Ren Q, Chen K, Paulsen IT. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Res 35, D274-9 (2007). WholeCell: PUB_0440, PubMed: 17135193, URL: http://membranetransport.org/

  5. Saier MH Jr, Tran CV, Barabote RD. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res 34, D181-6 (2006). WholeCell: PUB_0439, PubMed: 16381841, URL: http://www.tcdb.org/

  6. Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R. Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31, 6306-20 (2003). WholeCell: PUB_0569, PubMed: 14576319

 
Metadata
Created 2012-10-01 15:07:10
Last updated 2012-10-01 15:12:39