MG_014 – multidrug ABC transporter, ATP-binding/permease protein

Name
WID MG_014 View in model
Name multidrug ABC transporter, ATP-binding/permease protein View in model
Symbol mdlB
Protein product MG_014_MONOMER
Cross references GenBank: AAC71230.1, CMR: MG_014, BioCyc: MG_014, SwissProt: P47260
Homologs
 
Classification
Type mRNA View in model
 
Structure
Structure 1305519927 MG_011 MG_012 MG_013 MG_014 MG_015 MG_018 View in model
Sequence Chromosome: Mgenitalium_Chr_1, Coordinate: 15555 (nt), Length: 1872 (nt), Direction: Forward, G/C content: 29.0%, Sequence:
1
51
101
151
201
251
301
351
401
451
501
551
601
651
701
751
801
851
901
951
1001
1051
1101
1151
1201
1251
1301
1351
1401
1451
1501
1551
1601
1651
1701
1751
1801
1851
ATGGGGCTTGTTTTAAAAGAATTTAACAATAAAATAAGAACAGCATTAAT
TCTCGCTCCTTTTTTCACTTTCGCTCAGATAGTGATTGATTTAATCATTC
CTTCTTTTTTAGCAAGTGCTATTTCAGTTGTGTTTTCAATTGATAAATTA
AAACAGGATGAGTCAGGCGGAAAGACAATTTCAGTTGATTTTATTGGTGG
GGCTAATATTAATTTTGCTAATGTAAGAGAAGCGCAAATAGTTTTAGCAA
CCACAGTTATTTTACTTGCATTATGTGGACTTTTTTTTGGTCTAATATCT
ATTTATTGTGCAAGTTATGTTTCAGCAAACACTTCTTTTCTATTAAGAAA
AAAGATCTTTGCAAAATTAATGCGAATCACAACCCCATCACATGACCATT
ATGGTTCTTCTACTTTATTAGTTAGATTAACAAATGATGTTTATTTGATG
GAGGTAATTGCTTTTGATTTTTTAAGGCTAATTATTCGTGCTCCGCTTTT
GTTTATAGGTGGATTAGTGTTTGCAGTAACTACAAATCAAGATATGTCAA
TATCTTTACTAATTACTTTTCCTTTGATTCTTTTGGTAATTGGTATTCTA
AACCGTAAATCTATTCCTTTATTTAAAGAAAATCAAAAATCAGTTGATAA
GATAAATGAAAGAGTAGAAGAAGATGTTTCAGGTTATAAAGTAATTCAAT
CTTTTAATCTTCATTCCTTTACAAATAACAAATTTAAGATTGCAAATGAA
GGATGAAAAAAGAATAGTACAAGTTCTTTATTTATAAACTCACTTAACAT
TCCATTTACCTTTTTTTTAAGCAGTTTAACTATTATTATTGCTCTACTAT
TAGTTTTTCAATTAGATAGTAGTGTTTCAGTTGACCCATTACCGCAGGAT
GCAGCTATTAGACCTAATATCTTTGCTTTTTTCCAATATAACTTTTACAT
TGTTTTAGGGTTTATCTTAACCTCTTTAACAATGGTGAACTTTAATCGTT
CTAGAGTTGCACTAGGCAGAATTAAAGATATTTTATCTCAGCCTGAAATA
AAAACTATTACAAATAAAGATCAAAAAGAATTATTACCTACCTTGGAGTT
TAGAAATATCTCTTTTGGTCTTGGCAATAAGAACAATAACAATTTTTTAC
AAAATCTTAGTTTTAAATTTGAAGCATATAAAACATATGGTATTGTTGGG
CCTACAGGCTCTGGAAAATCTTTAATTGCTAACATTATCGGTGGTTTATA
TGAGCCTAATGAGGGTGAAATTCTCATTGGTGGGGAGAAAATTCAATCTA
TTGACAGTTTATATCTATCAGAAATGATAGGAATTGTTTTCCAACAAAAC
ATCCTTTTTAAAGGAACAATTTCTTCTAATATAAAAATTGGTATTGAAAC
TAGAAGTGATTGAAAGAATCAATCTGATTTACAAAAGAATGAAGCGATGA
AAAACGCAGCTAAAATAGCTTGCGCTGACACCTTTATTGAAAAGTTTTCT
GATAGTTATGATCACAATGTTGAACAGTTAGGTAAAAACTTATCTGGTGG
ACAAAAACAAAGAGTTGCTATTGCAAGAACTTTAATTACAAAACCAAGAA
TTTTAGTTTTTGATGATAGTATGAGTGCTCTTGATGCTCTAACTGAAAAA
AAAGTAAGAGAAAATATTGAAAATGATTTAAAGCTAACTACCAAAATCAT
TATTAGTCAAAACATTAATTCAATTAAACACGCAGATAAAATTTTGGTAA
TTGATAATGGCAGAATTGTTGGTTTTGATAGTGATCAAAAGCTAATGAAA
AATTGTTCACTTTATCAAAAGATGAAAGAATCTCAAAAAGATTTGGGAGG
TGATTTTGATGCAGTTAACTAG
50
100
150
200
250
300
350
400
450
500
550
600
650
700
750
800
850
900
950
1000
1050
1100
1150
1200
1250
1300
1350
1400
1450
1500
1550
1600
1650
1700
1750
1800
1850
1872
View in model
Transcription unit TU_008 View in model
Empirical formula (pH 7.5) H19917C18044N7332O13127P1872
Molecular weight (pH 7.5; Da) 607499.62 View in model
 
Functional genomics
Is essential
Yes (Show evidence)
View in model
Relative expression
0.560583 (dimensionless) (Show evidence)
View in model
Half life
3.7 (min) (Show evidence)
View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)
19453000
pI 4.22
 
Comments
Comments no predicted substrate binding protein in M. genitalium; similar to multidrug resistant transporters of eukarya [PUB_0241, PUB_0439, PUB_0440]; functions as dimer;
References
  1. Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A 99, 9697-702 (2002). WholeCell: PUB_0602, PubMed: 12119387

  2. Glass JI, Assad-Garcia N, Alperovich N, Yooseph S, Lewis MR, Maruf M, Hutchison CA 3rd, Smith HO, Venter JC. Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A 103, 425-30 (2006). WholeCell: PUB_0193, PubMed: 16407165

  3. Kuroda T, Tsuchiya T. Multidrug efflux transporters in the MATE family. Biochim Biophys Acta 1794, 763-8 (2009). WholeCell: PUB_0241, PubMed: 19100867

  4. Ren Q, Chen K, Paulsen IT. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Res 35, D274-9 (2007). WholeCell: PUB_0440, PubMed: 17135193, URL: http://membranetransport.org/

  5. Saier MH Jr, Tran CV, Barabote RD. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res 34, D181-6 (2006). WholeCell: PUB_0439, PubMed: 16381841, URL: http://www.tcdb.org/

  6. Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R. Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31, 6306-20 (2003). WholeCell: PUB_0569, PubMed: 14576319

 
Metadata
Created 2012-10-01 15:07:10
Last updated 2012-10-01 15:12:39