DNADamage_THY_O2mTHY_MNNG – DNA base methylation (thymine ==> 2'-O-methylthymine; N-methyl-N'-nitro-N-nitrosoguanidine)

Name
WID DNADamage_THY_O2mTHY_MNNG View in model
Name DNA base methylation (thymine ==> 2'-O-methylthymine; N-methyl-N'-nitro-N-nitrosoguanidine) View in model
 
Classification
Type base_methylation View in model
 
Reaction
Stoichiometry [c]: MNNG + THYNNG + O2mTHY View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) True View in model
 
Associations
Process Process_DNADamage View in model
 
Comments
Comments methylated predominantly in ssDNA by SN2 agents (eg. MMS), 20% of DNA methylation [PUB_0465]; relative rate: 0% MNNG methylations [PUB_0467]
References
  1. Beranek DT. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat Res 231, 11-30 (1990). WholeCell: PUB_0467, PubMed: 2195323

  2. Sedgwick B. Repairing DNA-methylation damage. Nat Rev Mol Cell Biol 5, 148-57 (2004). WholeCell: PUB_0465, PubMed: 15040447

 
Metadata
Created 2012-10-01 15:08:32
Last updated 2012-10-01 15:16:25