DNADamage_SpontaneousBaseDeamination_m5C – Spontaneous base deamination (5-methylcytosine ==> thymine)

Name
WID DNADamage_SpontaneousBaseDeamination_m5C View in model
Name Spontaneous base deamination (5-methylcytosine ==> thymine) View in model
Cross references EC: 3.5.4.-
 
Classification
Type spontaneous_base_deamination View in model
 
Reaction
Stoichiometry [c]: H2O + m5CSNNH3 + THY View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) True View in model
 
Associations
Process Process_DNADamage View in model
 
Comments
Comments Cytosine spontaneously deaminates with half-life 20,000 years in dsDNA [PUB_0506]. Adenine spontaneously deaminates at 2% the rate of cytosine [PUB_0506]. We assume that 5-methylcytosine spontaneously deaminates at a similar rate to that of adenine.
References
  1. Burdon RH. Genes and the environment. CRC Press (1999). WholeCell: PUB_0506, ISBN: 9780748408269

 
Metadata
Created 2012-10-01 15:08:31
Last updated 2012-10-01 15:16:23