DNADamage_CSNTHY_CSN64THY_UVB_radiation – DNA photodimerization (2'-deoxycytidine-p-2'-deoxythymidine ==> 2'-deoxycytidine-[6,4]-2'-deoxythymidine; UV-B)

Name
WID DNADamage_CSNTHY_CSN64THY_UVB_radiation View in model
Name DNA photodimerization (2'-deoxycytidine-p-2'-deoxythymidine ==> 2'-deoxycytidine-[6,4]-2'-deoxythymidine; UV-B) View in model
 
Classification
Type UV-B_photodimerization View in model
 
Reaction
Stoichiometry CSN[c] + THY[c] + UVB_radiation[e] ⇒ CSN64THY[c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) True View in model
 
Associations
Process Process_DNADamage View in model
 
Comments
Comments Reaction rate calculated from 1) total cyclopyrimidine yield (0.3/10^8 DA/J/m^2 [PUB_0480]), 2) cyclopyrimidine dimers 80% UV-B induced dimers, 6,4-photoproducts and dewar products 20%, 3-4% other [PUB_0492] 3) 305 DA/nt (assumes GC content 31.68%), 4) relative yields of cyclopyrimidine dimers CC: 3%, TC: 16%, CT: 13%, TT: 68% [PUB_0490, PUB_0491], 4) relative yield fo 6,4 photoproducts: TT: 66/40, CT: 10/110, TC: 34/110, CC: 0/110 [PUB_0493], 5) 6,4-photoproducts rapidly isomerize to dewar products.
References
  1. Clingen PH, Arlett CF, Roza L, Mori T, Nikaido O, Green MH. Induction of cyclobutane pyrimidine dimers, pyrimidine(6-4)pyrimidone photoproducts, and Dewar valence isomers by natural sunlight in normal human mononuclear cells. Cancer Res 55, 2245-8 (1995). WholeCell: PUB_0491, PubMed: 7757971

  2. Kaye GWC, Laby TH. Tables of physical and chemical constants. Longman Sc & Tech 2.7.7 (1995). WholeCell: PUB_0490, ISBN: 9780582226296, URL: http://www.kayelaby.npl.co.uk/

  3. Kufe DW, Frei E, Holland JF. Cancer medicine-6 review. BC Decker Inc Ch 20 (2003). WholeCell: PUB_0492, ISBN: 9781550092219, URL: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed6

  4. LeClerc JE, Borden A, Lawrence CW. The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coli. Proc Natl Acad Sci U S A 88, 9685-9 (1991). WholeCell: PUB_0493, PubMed: 1946387

  5. Mitchell DL, Jen J, Cleaver JE. Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation. Nucleic Acids Res 20, 225-9 (1992). WholeCell: PUB_0480, PubMed: 1311069

 
Metadata
Created 2012-10-01 15:08:30
Last updated 2012-10-01 15:16:18