DHdT – 5,6-dihydro-2'-deoxythymidine

Name
WID DHdT View in model
Name 5,6-dihydro-2'-deoxythymidine View in model
Traditional name 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione
IUPAC name 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione
Cross references PubChem: 10255868, CAS: 5627-00-9
 
Classification
Type modified_deoxyribonucleoside View in model
 
Structure
Empirical formula (pH 7.5) H16C10N2O5
SMILES (pH 7.5) CC1CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 244.24 View in model
van der Waals volume 
(pH 7.5; Å3 molecule‑1)
213.08
pI 4.38
logP -1.33
logD (pH 7.5) -1.33
 
Function
Reaction participant View in model
 
Comments
Comments recognized by endonuclease III, FPG, UNG [PUB_0473]
References
  1. Hatahet Z, Kow YW, Purmal AA, Cunningham RP, Wallace SS. New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase. J Biol Chem 269, 18814-20 (1994). WholeCell: PUB_0473, PubMed: 8034633

 
Metadata
Created 2012-10-01 15:06:54
Last updated 2012-10-01 15:12:02