AcpS – acyl-carrier protein synthase

Name
WID	AcpS
Name	acyl-carrier protein synthase
Cross references	EC: 2.7.8.7, SABIO-RK: 542, BiGG: ACPS1, BioCyc: HOLO-ACP-SYNTH-RXN

Classification
Type	chemical

Reaction
Stoichiometry	[c]: COA + MG_287_MONOMER ⇒ H + MG_287_MONOMER_ACP + PAP

Catalysis
Enzyme	MG_482_DIMER [c]
Optimal pH	7.1 (dimensionless)
Optimal temperature	48.0 (C)

Energetics
Is spontaneous (pH 7.5, 25C, I = 0)	False
ΔG (pH 7.5, 25C, I = 0; kJ mol^‑1)	-3.80
K_eq	550.954774449 ()

Kinetics
Forward kinetics	v = V_max * [MG_287_MONOMER] / (K_m + [MG_287_MONOMER]); K_m = 68 (nM), V_max = 125.0 1/min (Show evidence) Value: Km = CoA 50 (None) Measured: Yes Species: Escherichia coli References Keseler IM, Bonavides-Martínez C, Collado-Vides J, Gama-Castro S, Gunsalus RP, Johnson DA, Krummenacker M, Nolan LM, Paley S, Paulsen IT, Peralta-Gil M, Santos-Zavaleta A, Shearer AG, Karp PD. EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res 37, D464-70 (2009). WholeCell: PUB_0006, PubMed: 18974181 Value: Rate law: VmaxAPOACP/(Km+APOACP); Km = 68 uM, Vmax = 125 1/min (None) Measured: Yes* Species: Bacillus subtilis References Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Associations
Pathways	ARG_PRO_METABOLISM
Process	Process_Metabolism

Comments
References	Keseler IM, Bonavides-Martínez C, Collado-Vides J, Gama-Castro S, Gunsalus RP, Johnson DA, Krummenacker M, Nolan LM, Paley S, Paulsen IT, Peralta-Gil M, Santos-Zavaleta A, Shearer AG, Karp PD. EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res 37, D464-70 (2009). WholeCell: PUB_0006, PubMed: 18974181 Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Metadata
Created	2012-10-01 15:08:05
Last updated	2012-10-01 15:14:55


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