AP_endonuclease – 5'-apurinic/apyrimidinic endonuclease

Name
WID AP_endonuclease View in model
Name 5'-apurinic/apyrimidinic endonuclease View in model
Cross references EC: 4.2.99.18
 
Classification
Type base_excision_repair View in model
 
Reaction
Stoichiometry [c]: dRibose5P_dRibose5P + H2O ⇒ (2) DR5P + H View in model
 
Catalysis
Enzyme MG_235_MONOMER [c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
 
Kinetics
Forward kinetics Km1 = 6 (nM), Km2 = 140 (nM), Vmax = 184.8 1/min View in model
 
Associations
Process Process_DNARepair View in model
 
Comments
Comments Reaction Vmax and Km cataloged in [PUB_0488].
References
  1. Sokhansanj BA, Rodrigue GR, Fitch JP, Wilson DM 3rd. A quantitative model of human DNA base excision repair. I. Mechanistic insights. Nucleic Acids Res 30, 1817-25 (2002). WholeCell: PUB_0488, PubMed: 11937636

 
Metadata
Created 2012-10-01 15:08:05
Last updated 2012-10-01 15:14:56